PRe-ART-2T
We aim to disrupt the reagent antibody market

PRe-ART-2T is an innovative project funded by the European Commission, Innovate UK and the Swiss National Science Foundation
and aims for establishing a modular reagent binder system as an alternative to reagent antibodies

Learn More

About Us

Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to replace conventional reagent antibody technology.

In a multidisciplinary approach combining basic science, protein engineering and computational prediction, PRe-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market.

Img

By clicking on the thumbnail, you will leave our site and be redirected to www.youtube-nocookie.com. Despite data protection-friendly integration, YouTube may use cookies. Please refer to the privacy policy of YouTube or Google for more information.

Img Img Img

Our Objectives

The fundamental objective of the project is to change the way how binding proteins are generated.

For forty years, biological research has relied on monoclonal antibodies (mAbs) to detect biomolecules with-in medical diagnostics and basic life science research (reagent antibodies are not used in therapy, rather, they are used in vitro to detect biomolecules in virtually all biological and biomedical research, and also in clinical diagnostics). Without them, detection of disease-state biomarkers would be impossible and indeed, much fundamental life science research is absolutely dependent on mAbs.

Yet unfortunately, it has become more and more evident that many mAbs are not nearly as specific as presumed, many mAbs are very poorly characterized and their production is based on unstable cell lines. In fact, about half of the commercial reagent mAbs have been shown to not function correctly.

The present project will solve this problem by the creation of protein modules, specific for very short stretches of peptide chains, from which modular binders (whole proteins) can be assembled.

View Review Article

Our Techniques

Advances in the following techniques will help us establish this disruptive system:

Protein Design

We computationally and experimentally create binding capability

Evolutionary Protein Engineering

We leverage evolutionary information on ligand detection

DNA Libraries

We can create very precise DNA libraries that exclusively encode required amino acids at specified positions

Structural Biology

We determine structural information about the protein-peptide complex

Learn how we collaborate.

Read more about what we do, who we are, and how we come together as a consortium.
Meet our highly experienced team who just love proteins.

Get to know the team

Dissemination

How we spread the word about PRe-ART-2T.

Workshops

Where we meet to elevate PRe-ART-2T.

Contact

Find out how to contact us
Up!